Symbol
Name
ID

Atm
ataxia telangiectasia mutated
MGI:107202

Phenotype annotations related to immune system

*	Aspects of the system are reported to show a normal phenotype.
	Darker colors indicate more annotations

Human Phenotypes

Decreased circulating IgA level

Decreased circulating IgG level

Decreased circulating IgG2 level

Defective B cell differentiation

Abnormal B cell count

Decreased proportion of CD4-positive helper T cells

T lymphocytopenia

Lymphopenia

Leukemia

Acute lymphoblastic leukemia

Sinusitis

Lymphadenopathy

Hypoplasia of the thymus

Hepatosplenomegaly

Peritoneal abscess

Recurrent lower respiratory tract infections

Recurrent bronchitis

Disease(s) Associated with ATM

ataxia telangiectasia

pancreatic cancer

Mouse Phenotypes

immune system phenotype

impaired macrophage phagocytosis

thymus cortex hypoplasia

small thymus

decreased thymocyte number

enlarged spleen

abnormal class switch recombination

decreased immature B cell number

abnormal T cell differentiation

abnormal CD4-positive T cell differentiation

abnormal CD8-positive, alpha-beta T cell differentiation

increased double-negative T cell number

decreased double-positive T cell number

increased double-positive T cell number

increased B-1 B cell number

increased B-1a cell number

decreased B cell number

decreased pre-B cell number

increased B cell number

increased central memory CD4-positive, alpha-beta T cell number

increased effector memory CD4-positive, alpha-beta T cell number

decreased CD4-positive, alpha-beta T cell number

increased central memory CD8 positive, alpha-beta T cell number

increased CD8-positive, alpha-beta memory T cell number

decreased CD8-positive, naive alpha-beta T cell number

decreased CD8-positive, alpha-beta T cell number

decreased T cell number

decreased activated T cell number

decreased single-positive T cell number

increased single-positive T cell number

decreased lymphocyte cell number

increased macrophage cell number

abnormal lymphocyte morphology

small spleen

decreased splenocyte number

decreased IgG2a level

decreased IgG2b level

decreased IgG3 level

decreased IgG level

increased IgM level

abnormal T cell physiology

abnormal microglial cell physiology

abnormal immune system cell morphology

abnormal immune system organ morphology

small lymph nodes

impaired humoral immune response

decreased interleukin-1 beta secretion

decreased response to antigen

Availability

Mouse Genotype

Atm^m1Btlr/Atm^m1Btlr

Atm^m2Btlr/Atm^m2Btlr

Atm^m3Btlr/Atm^m3Btlr

Atm^M4Btlr/Atm^M4Btlr

Atm^m5Btlr/Atm^m5Btlr

Atm^m6Btlr/Atm^m6Btlr

Atm^tm1.1Mmpl/Atm^tm1.1Mmpl

Atm^tm1Awb/Atm^tm1Awb

Atm^tm1Bal/Atm^tm1Bal

Atm^tm1Fwa/Atm^tm1Fwa

Atm^tm1Led/Atm^tm1Led

Atm^tm1Mfl/Atm^tm1Mfl

Atm^tm2.1Mfgc/Atm^tm2.1Mfgc

Atm^tm2.1Fwa/Atm^tm2.1Fwa
Tg(VAV1-cre)1Graf/0 (conditional)

Atm^tm1Shzh/Atm^tm2.1Fwa
Gt(ROSA)26Sor^{tm1(cre/ERT2)Thl}/Gt(ROSA)26Sor⁺ (conditional)

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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